In this article we describe a new wireless biosignal system which monitors in a long-term basis, the users at their homes. The system consists of wearable sensors that measure heart rate, blood oxygen saturation and physical activity levels, sending data to a mobile phone and from this to a remote monitoring station located in a clinical facility. Whenever an abnormal situation occurs, an alarm is triggered and caregivers can provide assistance. The system has been deployed at a major Portuguese public hospital and 30 patients under long-term oxygen therapy have been continuously monitored remotely. The results report that the patients feel comfortable and safe when they are continuously remote monitored and for caregivers the system allows them to optimize their time and give better and faster assistance.