Abstract -- The application of Orthogonal SpaceTime Block Codes (O-STBC) as the encoding scheme in the presence of "non-quasi-static" fading was considered. A simple and efficient adaptive method of channel estimation based on the interpolation of estimates acquired at the pre-amble and post-amble of framed blocks of information is developed. Moreover, the proposed method is proven, both theoretically and by simulations, to outperform the alternative of channel tracking, despite its significant low complexity. Keywords -- STBC, Channel Estimation, Interpolation, non-quasi-static fading