Analysis of integrated biomolecular networks using a generic network analysis suite

The informative value of biomolecular networks has shifted from being solely information resources for possible cellular partners (whether these embody proteins, (ribo)nucleic acids or small molecules) towards becoming models for the functional connectivity within a cell. These models are increasingly exploited to make quantitative predictions about the cell’s functional organization as well as about the functionality of individual elements in the network. A large number of concepts and methods have been proposed in order to interpret experimental data mapped to cellular networks these systems and to make use of the rich source of information they represent. We will present a system for the Comprehensive Analysis of Biomolecular Networks (CABiNet), capable of integrating available network analysis methods. Integration is done by classifying each method into one of four separate categories using standardized interfaces that encapsulate the functionality of the method in a distinct co...

• Type: Journal
• Year: 2007
• Where: JIB
• Authors: Matthias Oesterheld, Hans-Werner Mewes, Volker Stümpflen
• Keywords: Biomolecular Networks, JIB 2007, Network Analysis Methods, Possible Cellular Partners