An antimagic labeling of an undirected graph G with n vertices and m edges is a bijection from the set of edges of G to the integers {1, . . . , m} such that all n vertex sums are pairwise distinct, where a vertex sum is the sum of labels of all edges incident with that vertex. A graph is called antimagic if it admits an antimagic labeling. In [6], Hartsfield and Ringel conjectured that every simple connected graph, other than K2, is antimagic. Despite considerable effort in recent years, this conjecture is still open. In this paper we study a natural variation; namely, we consider antimagic labelings of directed graphs. In particular, we prove that every directed graph whose underlying undirected graph is “dense” is antimagic, and that almost every undirected d-regular graph admits an orientation which is antimagic.