: Motivated by the problem of out-of-shelf (OOS) in retail industry and the emergence of RFID (Radio Frequency Identification) technology, this paper investigates the impact that the adoption of RFID has on the quality of information utilized during the shelf replenishment process and consequently on the products’ shelf availability. A RFID-integrated decision support system (DSS) with three alternative implementation scenarios is proposed to enhance the shelf replenishment process. On one hand, the impact of the three alternative solutions on the quality of the DSS information input is examined in terms of accuracy, timeliness and completeness. On the other hand, the effect of the three alternative deployment scenarios of the RFID-integrated DSS on the OOS problem is assessed through measuring the number of OOS occurrences after utilizing the DSS. The quality of the DSS information input and the products’ shelf availability are assessed for each implementation scenario by executin...