AthaMap web tools for the analysis and identification of co-regulated genes

The AthaMap database generates a map of cisregulatory elements for the whole Arabidopsis thaliana genome. This database has been extended by new tools to identify common cis-regulatory elements in specific regions of user-provided gene sets. A resulting table displays all cis-regulatory elements annotated in AthaMap including positional information relative to the respective gene. Further tables show overviews with the number of individual transcription factor binding sites (TFBS) present and TFBS common to the whole set of genes. Over represented cis-elements are easily identified. These features were used to detect specific enrichment of drought-responsive elements in cold-induced genes. For identification of co-regulated genes, the output table of the colocalization function was extended to show the closest genes and their relative distances to the colocalizing TFBS. Gene sets determined by this function can be used for a co-regulation analysis in microarray gene expression databas...

• Type: Journal
• Year: 2007
• Where: NAR
• Authors: Claudia Galuschka, Martin Schindler, Lorenz Bülow, Reinhard Hehl
• Keywords: Cis-regulatory Elements, Common Cis-regulatory Elements, Gene, NAR 2007