As a new branch of grid computing, e-Learning grid is emerging as a nationwide e-Learning infrastructure, which can provide innovative learning experience for learners. In such a grid environment, collaboration services will be the key elements due to the pervasive requirement for cooperative work and collaborative learning. Although there exist enormous research efforts on grid-based collaboration technologies, most of them have many limitations. In this paper, with the findings from the computer support cooperative work (CSCW)/computer support collaborative learning (CSCL) and advantages provided by grid, we propose to build grid-enabled large-scale collaboration environment (GLCE). GLCE focuses on distributed, large-scale, and cross-organizational collaboration through creating group-centered next generation collaboration environment, where both intra-group and inter-group collaboration could be supported. With this idea in mind, we present a grid-based cooperative work framework (...