In order to become an effective complement to traditional Web-scale text-based image retrieval solutions, content-based image retrieval must address scalability and efficiency issues. In this paper we investigate the possibility of caching the answers to content-based image retrieval queries in metric space, with the aim of reducing the average cost of query processing, and boosting the overall system throughput. Our proposal exploits the similarity between the query object and the cache content, and allows the cache to return approximate answers with acceptable quality guarantee even if the query processed has never been encountered in the past. Moreover, since popular images that are likely to be used as query have several near-duplicate versions, we show that our caching algorithm is robust, and does not suffer of cache pollution problems due to near-duplicate query objects. We report on very promising results obtained with a collection of one million high-quality digital photos. W...