CellCircuits: a database of protein network models

CellCircuits (http://www.cellcircuits.org) is an openaccess database of molecular network models, designed to bridge the gap between databases of individual pairwise molecular interactions and databases of validated pathways. CellCircuits captures the output from an increasing number of approaches that screen molecular interaction networks to identify functional subnetworks, based on their correspondence with expression or phenotypic data, their internal structure or their conservation across species. This initial release catalogs 2019 computationally derived models drawn from 11 journal articles and spanning five organisms (yeast, worm, fly, Plasmodium falciparum and human). Models are available either as images or in machinereadable formats and can be queried by the names of proteins they contain or by their enriched biological functions. We envision CellCircuits as a clearinghouse in which theorists may distribute or revise models in need of validation and experimentalists may sear...

• Type: Journal
• Year: 2007
• Where: NAR
• Authors: H. Craig Mak, Mike Daly, Bianca Gruebel, Trey Ideker
• Keywords: Databases, Molecular Interaction, NAR 2007, Network Models