Characterizing Task-Related Temporal Dynamics of Spatial Activation Distributions in fMRI BOLD Signals

We present a new functional magnetic resonance imaging (fMRI) analysis method that incorporates both spatial and temporal dynamics of bloodoxygen-level dependent (BOLD) signals within a region of interest (ROI). 3D moment descriptors are used to characterize the spatial changes in BOLD signals over time. The method is tested on fMRI data collected from eight healthy subjects performing a bulb-squeezing motor task with their right-hand at various frequencies. Multiple brain regions including the left cerebellum, both primary motor cortices (M1), both supplementary motor areas (SMA), left prefrontal cortex (PFC), and left anterior cingulate cortex (ACC) demonstrate significant task-related changes. Furthermore, our method is able to discriminate differences in activation patterns at the various task frequencies, whereas using a traditional intensity based method, no significant activation difference is detected. This suggests that temporal dynamics of the spatial distribution of BOLD sig...

• Type: Conference
• Year: 2007
• Where: MICCAI
• Authors: Bernard Ng, Rafeef Abugharbieh, Samantha J. Palmer, Martin J. McKeown
• Keywords: Intensity Based Method, Medical Imaging, MICCAI 2007, Significant Activation Difference, Various Task Frequencies