Chromosomal clustering of a human transcriptome reveals regulatory background

Background: There has been much evidence recently for a link between transcriptional regulation and chromosomal gene order, but the relationship between genomic organization, regulation and gene function in higher eukaryotes remains to be precisely defined. Results: Here, we present evidence for organization of a large proportion of a human transcriptome into gene clusters throughout the genome, which are partly regulated by the same transcription factors, share biological functions and are characterized by non-housekeeping genes. This analysis was based on the cardiac transcriptome identified by our genome-wide array analysis of 55 human heart samples. We found 37% of these genes to be arranged mainly in adjacent pairs or triplets. A significant number of pairs of adjacent genes are putatively regulated by common transcription factors (p = 0.02). Furthermore, these gene pairs share a significant number of GO functional classification terms. We show that the human cardiac transcriptom...

• Type: Journal
• Year: 2005
• Where: BMCBI
• Authors: Jan H. Vogel, Anja von Heydebreck, Antje Purmann, Silke Sperling
• Keywords: BMCBI 2005, Cardiac Transcriptome, Gene, Transcription Factors