This paper addresses the issue of effective and efficient content based image retrieval by presenting a novel indexing and retrieval methodology that integrates color, texture, and shape information for the indexing and retrieval, and applies these features in regions obtained through unsupervised segmentation, as opposed to applying them to the whole image domain. In order to address the typical color feature “inaccuracy” problem in the literature, fuzzy logic is applied to the traditional color histogram to solve for the problem to a certain degree. The similarity is defined through a balanced combination between global and regional similarity measures incorporating all the features. In order to further improve the retrieval efficiency, a secondary clustering technique is developed and employed to significantly save query processing time without compromising the retrieval precision. An implemented prototype system has demonstrated a promising retrieval performance for a test dat...