Abstract. In 1965 Motzkin and Straus established a remarkable connection between the local/global maximizers of the Lagrangian of a graph G over the standard simplex ∆ and the maximal/maximum cliques of G. In this work we generalize the Motzkin-Straus theorem to k-uniform hypergraphs, establishing an isomorphism between local/global minimizers of a particular function over ∆ and the maximal/maximum cliques of a k-uniform hypergraph. This theoretical result opens the door to a wide range of further both practical and theoretical applications, concerning continuous-based heuristics for the maximum clique problem on hypergraphs, as well as the discover of new bounds on the clique number of hypergraphs. Moreover we show how the continuous optimization task related to our theorem, can be easily locally solved by mean of a dynamical system.