COPASAAR - A database for proteomic analysis of single amino acid repeats

Background: Single amino acid repeats make up a significant proportion in all of the proteomes that have currently been determined. They have been shown to be functionally and medically significant, and are associated with cancers and neuro-degenerative diseases such as Huntington's Chorea, where a poly-glutamine repeat is responsible for causing the disease. The COPASAAR database is a new tool to facilitate the rapid analysis of single amino acid repeats at a proteome level. The database aims to simplify the comparison of repeat distributions between proteomes in order to provide a better understanding of their function and evolution. Results: A comparative analysis of all proteomes in the database (currently 244) shows that single amino acid repeats account for about 12

• Type: Journal
• Year: 2005
• Where: BMCBI
• Authors: Daniel P. Depledge, Andrew R. Dalby
• Keywords: Amino Acids, BMCBI 2005, Single Amino, Single Amino Acid