—Following the two trends of computerization and informatization, another emerging trend is cyberization in which numerous and various cyber entities in cyberspace will exist in cyber-enabled worlds including the cyber world and cyber-conjugated physical, social and mental worlds. Computer science and information science, as holistic fields, have respectively played important roles in computerization and informatization. Similarly, it is necessary for there to be a corresponding field for cyberization. Cybermatics is proposed as such a holistic field for the systematic study of cyber entities in cyberspace and cyber world, and their properties, functions and conjugations with entities in conventional spaces/worlds. This article sets out to explain the necessity and rationale for, and significance of, the proposed field of Cybermatics, what it is and what it encompasses, and how it is related to other fields and areas.