The Database of Macromolecular Motions: new features added at the decade mark

The database of molecular motions, MolMovDB 15 (http://molmovdb.org), has been in existence for the past decade. It classifies macromolecular motions and provides tools to interpolate between two conformations (the Morph Server) and predict possible motions in a single structure. In 2005, we expanded 20 the services offered on MolMovDB. In particular, we further developed the Morph Server to produce improved interpolations between two submitted structures. We added support for multiple chains to the original adiabatic mapping interpolation, allowing 25 the analysis of subunit motions. We also added the option of usingFRODAinterpolation,whichallowsfor more complex pathways, potentially overcoming steric barriers. We added an interface to a hinge prediction service, which acts on single structures and 30 predicts likely residue points for flexibility. We developed tools to relate such points of flexibility in a structure to particular key residue positions, i.e. active sites or highly c...

• Type: Journal
• Year: 2006
• Where: NAR
• Authors: Samuel Flores, Nathaniel Echols, Duncan Milburn, Brandon Hespenheide, Kevin Keating, Jason Lu, Stephen Wells, Eric Z. Yu, Michael Thorpe, Mark Gerstein
• Keywords: Molecular Motions, Morph Server, NAR 2006, Single Structures