As the number of integrated IP cores in the current System-on-Chips (SoCs) keeps increasing, communication requirements among cores can not be sufficiently satisfied using either traditional or multi-layer bus architectures because of their poor scalability and bandwidth limitation on a single bus. While new interconnection techniques have been explored to overcome such a limitation, the notion of utilizing Network-on-Chip (NoC) technologies for the future generation of high performance and low power chips for myriad of applications, in particular for wireless communication and multimedia processing, has been of great importance. In order for the NoC technologies to succeed, realistic specifications such as throughput, latency, moderate design complexity, programming model, and design tools are necessary requirements. For this purpose, we have covered some of the key and challenging design issues specific to the NoC architecture such as the router design, network interface (NI) issues...