Design, Simulation, and Experimental Demonstration of Self-assembled DNA Nanostructures and Motors

Self-assembly is the spontaneous self-ordering of substructures into superstructures driven by the selective affinity of the substructures. DNA provides a molecular scale material for programmable self-assembly, using the selective affinity of pairs of DNA strands to form DNA nanostructures. DNA self-assembly is the most advanced and versatile system that has been experimentally demonstrated for programmable construction of patterned systems on the molecular scale. The methodology of DNA self-assembly begins with the synthesis of single-strand DNA molecules that self-assemble into macromolecular building blocks called DNA tiles. These tiles have sticky ends that match the sticky ends of other DNA tiles, facilitating further assembly into larger structures known as DNA tiling lattices. In principle, DNA tiling assemblies can form any computable two or three-dimensional pattern, however complex, with the appropriate choice of the tiles’ component DNA. Two-dimensional DNA tiling latti...

• Type: Conference
• Year: 2004
• Where: UPP
• Authors: John H. Reif, Thomas H. LaBean, Sudheer Sahu, Hao Yan, Peng Yin
• Keywords: Artificial Intelligence, DNA Self-assembly, DNA Tiling Assemblies, DNA Tiling Lattices, UPP 2004