DFS-generated pathways in GA crossover for protein structure prediction

Genetic Algorithms (GAs), as nondeterministic conformational search techniques, are promising for solving protein structure prediction (PSP) problems. The crossover operator of a GA can underpin the formation of potential conformations by exchanging and sharing potential sub-conformations. However, as the optimum PSP conformation is usually compact, the crossover operation may result in many invalid conformations (by having non-self-avoiding-walk). Although a crossover-based converging conformation suffers from limited pathways, combining it with depth-first search (DFS) can partially reveal potential pathways and make an invalid crossover valid and successful. Random conformations are frequently applied for maintaining diversity as well as for initialization in many GA applications. Random-move-only-based conformation generator has exponential time complexity in generating random conformations, whereas the DFS based random conformation generator has linear time complexity and perform...

• Type: Journal
• Year: 2010
• Where: IJON
• Authors: Tamjidul Hoque, Madhu Chetty, Andrew Lewis, Abdul Sattar, Vicky M. Avery
• Keywords: Conformation Generator, IJON 2010, Random Conformation, Time Complexity