DynGO: a tool for visualizing and mining of Gene Ontology and its associations

Background: A large volume of data and information about genes and gene products has been stored in various molecular biology databases. A major challenge for knowledge discovery using these databases is to identify related genes and gene products in disparate databases. The development of Gene Ontology (GO) as a common vocabulary for annotation allows integrated queries across multiple databases and identification of semantically related genes and gene products (i.e., genes and gene products that have similar GO annotations). Meanwhile, dozens of tools have been developed for browsing, mining or editing GO terms, their hierarchical relationships, or their "associated" genes and gene products (i.e., genes and gene products annotated with GO terms). Tools that allow users to directly search and inspect relations among all GO terms and their associated genes and gene products from multiple databases are needed. Results: We present a standalone package called DynGO, which provi...

• Type: Journal
• Year: 2005
• Where: BMCBI
• Authors: Hongfang Liu, Zhang-Zhi Hu, Cathy H. Wu
• Keywords: BMCBI 2005, Databases, Gene Products, GO Annotations