An EM Algorithm for Ion-Channel Current Estimation

Parameter estimation of a continuous-time Markov chain observed through a discrete-time memoryless channel is studied. An expectation-maximization (EM) algorithm for maximum likelihood estimation of the parameter of this hidden Markov process is developed and applied to a simple example of modeling ion-channel currents in living cell membranes. The approach follows that of Asmussen, Nerman and Olsson, and Ryd

• Type: Journal
• Year: 2008
• Where: TSP
• Authors: William J. J. Roberts, Yariv Ephraim
• Keywords: Continuous-Time Markov Chain, Estimation, Parameter Estimation, TSP 2008