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ISBI
2004
IEEE

Evaluation of Arterial Endothelial Function Using Transit Times of Artificially Induced Pulses

15 years 4 days ago
Evaluation of Arterial Endothelial Function Using Transit Times of Artificially Induced Pulses
Background: Impairment of arterial endothelial function is an early event in atherosclerosis and correlates with the major risk factors for cardiovascular disease. The most widely employed non-invasive measure of endothelial function involves brachial artery (BA) diameter measurement using ultrasound imaging before and after several minutes of blood flow occlusion. The change in arterial diameter is a measure of flow-mediated vasorelaxation (FMVR). The high between-laboratory variability of results and cost of instrumentation render this technique unsuitable for routine clinical use. Methods and results: We induce artificial pulses at the superficial radial artery using a linear actuator. An ultrasonic Doppler stethoscope detects these pulses 10-30cm proximal to the point of pulse induction. The delay between pulse application and detection provides the pulse transit time (PTT). By measuring PTT before and after 5 minutes of BA occlusion and ensuing reactive hyperemia, FMVR may be mea...
Jonathan Maltz, Thomas Budinger
Added 20 Nov 2009
Updated 20 Nov 2009
Type Conference
Year 2004
Where ISBI
Authors Jonathan Maltz, Thomas Budinger
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