Exploiting Codon-Triplets Association for Genome Primary Structure Analysis

— The way evolution shapes the arrangement of synonymous codons within open reading frames (ORF) for fine tuning mRNA decoding efficiency is not yet understood. Since the ribosome has 3 tRNA binding sites, the context of triplets should be relevant to decoding fidelity and efficiency. We have developed a software application for large-scale analysis of codon-triplet associations to shed new light into this problem. The developed algorithms identify codon-triplets context biases, allowing for large scale comparative codon-triplet analysis and for identification of alterations to the standard genetic code.

• Type: Conference
• Year: 2008
• Where: BIOTECHNO
• Authors: José P. Lousado, Gabriela R. Moura, Manuel A. S. Santos, José Luís Oliveira
• Keywords: Bioinformatics, BIOTECHNO 2008, Codon-triplets Context Biases, MRNA Decoding Efficiency, Open Reading Frames