Exploiting Quasiperiodicity in Motion Correction of Free-Breathing Myocardial Perfusion MRI

Free-breathing image acquisition is desirable in first-pass gadolinium- enhanced magnetic resonance imaging (MRI), but the breathing movements hinder the direct automatic analysis of the myocardial perfusion and qualitative readout by visual tracking. Nonrigid registration can be used to compensate for these movements but needs to deal with local contrast and intensity changes with time. We propose an automatic registration scheme that exploits the quasiperiodicity of free breathing to decouple movement from intensity change. First, we identify and register a subset of the images corresponding to the same phase of the breathing cycle. This registration step deals with small differences caused by movement but maintains the full range of intensity change. The remaining images are then registered to synthetic references that are created as a linear combination of images belonging to the already registered subset. Because of the quasiperiodic respiratory movement, the subset images are dis...

• Type: Journal
• Year: 2010
• Where: TMI
• Authors: Gert Wollny, María J. Ledesma-Carbayo, Peter Kellman, Andrés Santos
• Keywords: Images, Intensity Change, Management, Perfusion Profiles, TMI 2010