: Adolescent cancer patients have to deal with many dependencies and obligations. Very often they are torn out of their social environment and become isolated because of changing therapy cycles and different treatment locations. This causes significant social and economic damage. The objective of this article is to present the first steps of an empirical exploration of the possibilities of mobile IT support for communication and coordination for this target group during treatment and aftercare. Special emphasis is put on the effects of mobile systems on the patient’s perceived quality of life. The background we bring to the fore is a four-month field experiment conducted together with the cancer station of the hospital of Heidelberg University. We focus on particularities of and challenges for mobile information systems for patients in Germany and outline necessary future research aspects in this field.