To date the adoption and diffusion of technology enabled solutions to deliver better healthcare has been slow. There are many reasons for this. One of the most significant is that existing methodologies that are normally used in general for ICT (information communication technology) implementations tend to be less successful in a healthcare context. This paper describes a knowledge-based adaptive mapping to realization methodology that provides a means to traverse from idea to realization rapidly and yet without compromising rigor so that success ensues. It is discussed in connection with trying to implement superior ICT enabled approaches for facilitating superior chronic disease management. Key words chronic disease management, diabetes, ICT, healthcare knowledge-based methodology Chronic Disease Management Containment of cost and yet offering the highest quality healthcare has become a global priority for healthcare delivery. In such an environment prevention and/or early detection...