Flexibility Description of the MET Protein Stalk Based on the Use of Non-uniform B-Splines

Abstract. The MET protein controls growth, invasion, and metastasis in cancer cells and is thereby of interest to study, for example from a structural point of view. For individual particle imaging by Cryo-Electron Tomography of the MET protein, or other proteins, dedicated image analysis methods are required to extract information in a robust way as the images have low contrast and resolution (with respect to the size of the imaged structure). We present a method to identify the two parts of the MET protein, -propeller and stalk, using a fuzzy framework. Furthermore, we describe how a representation of the MET stalk, denoted stalk curve, can be identified based on the use of non-uniform B-splines. The stalk curve is used to extract relevant geometrical information about the stalk, e.g., to facilitate curvature and length measurements.

• Type: Conference
• Year: 2007
• Where: CAIP
• Authors: Magnus Gedda, Stina Svensson
• Keywords: CAIP 2007, Image Analysis, MET Protein, MET Stalk, Stalk Curve