FragViz: visualization of fragmented networks

Background: Researchers in systems biology use network visualization to summarize the results of their analysis. Such networks often include unconnected components, which popular network alignment algorithms place arbitrarily with respect to the rest of the network. This can lead to misinterpretations due to the proximity of otherwise unrelated elements. Results: We propose a new network layout optimization technique called FragViz which can incorporate additional information on relations between unconnected network components. It uses a two-step approach by first arranging the nodes within each of the components and then placing the components so that their proximity in the network corresponds to their relatedness. In the experimental study with the leukemia gene networks we demonstrate that FragViz can obtain network layouts which are more interpretable and hold additional information that could not be exposed using classical network layout optimization algorithms. Conclusions: Netw...

• Type: Journal
• Year: 2010
• Where: BMCBI
• Authors: Miha Stajdohar, Minca Mramor, Blaz Zupan, Janez Demsar
• Keywords: BMCBI 2010, Layout Optimization Technique, Network Visualization, Unconnected Components