In this paper, we propose a framework to develop highperformance system accelerator hardware and the corresponding software at system-level. This framework is designed by integrating a virtual machine, an electronic system level platform, and an enhanced QEMU-SystemC. The enhancement includes a local master interface for fast memory transfer, and an interrupt handling hardware for software/hardware communication that enables full system simulation. Finally, the PAC DSP core is used as examples to demonstrate the proposed framework for full system simulation.