Generating GO Slim Using Relational Database Management Systems to Support Proteomics Analysis

The Gene Ontology Consortium built the Gene Ontology database (GO) to address the need for a common standard in naming genes and gene products. Using different names for the same concepts and different concepts with the same name makes it effectively impossible for humans and computers alike to analyze biological processes across different organisms. The consortium addresses this need by defining terms for categorizing genes and gene products. A convention in GO is that each gene or gene product is annotated to the most specific GO term in the GO database. It is, however, also useful for researchers to be able to group genes or gene products into broad biological categories that give a higher-level view of their function when analyzing results of an experiment. A GO Slim is a subset of the GO ontology that provides such a higher-level view of functions. Existing GO Slim generation tools have two important limitations: programming language dependence, and an inability to dynamically ge...

• Type: Conference
• Year: 2008
• Where: CBMS
• Authors: Getiria Onsongo, Hongwei Xie, Timothy J. Griffin, John Carlis
• Keywords: CBMS 2008, Gene Ontology, Gene Products, GO Slim, Medical Imaging