HGBASE: a database of SNPs and other variations in and around human genes

Human genome polymorphism is expected to play a key role in defining the etiologic basis of phenotypic differences between individuals in aspects such as drug responses and common disease predisposition. Relevant functional DNA changes will probably be located in or near to transcribed sequences, and include many single nucleotide polymorphisms. To aid the future analysis of such genome variation, HGBASE (Human Genic Bi-Allelic SEquences) was constructed as a means to gather human gene-linked polymorphisms from all possible public sources, and show these as a non-redundant set of records in a standardized and user-friendly database endowed with text and sequence based search facilities. After 1 year of presence on the WWW, the HGBASE project has compiled data for over 22 000 records, and this number continues to triple every 6

• Type: Journal
• Year: 2000
• Where: NAR
• Authors: Anthony J. Brookes, Heikki Lehväslaiho, Marianne Siegfried, Jana G. Boehm, Yan P. Yuan, Chandra M. Sarkar, Peer Bork, J. Flavio R. Ortigao
• Keywords: Genic Bi-Allelic SEquences, Human Genome Polymorphism, NAR 2000, Single Nucleotide Polymorphisms