A Hidden Markov Model for de Novo Peptide Sequencing

De novo Sequencing of peptides is a challenging task in proteome research. While there exist reliable DNA-sequencing methods, the highthroughput de novo sequencing of proteins by mass spectrometry is still an open problem. Current approaches suffer from a lack in precision to detect mass peaks in the spectrograms. In this paper we present a novel method for de novo peptide sequencing based on a hidden Markov model. Experiments effectively demonstrate that this new method significantly outperforms standard approaches in matching quality.

• Type: Conference
• Year: 2004
• Where: NIPS
• Authors: Bernd Fischer, Volker Roth, Joachim M. Buhmann, Jonas Grossmann, Sacha Baginsky, Wilhelm Gruissem, Franz F. Roos, Peter Widmayer
• Keywords: De Novo Sequencing, NIPS 2004, NIPS 2007, Novo Peptide, Novo Sequencing