iCircos: visual analytics for translational bioinformatics

Translational bioinformatics increasingly involves the discovery of associations between molecular and phenotype information, with the goal of transforming those discoveries into novel methods for diagnosis and treatment. To enable such complex analyses, researchers need approaches that provide the simultaneous representation and interactive analysis of patients, and their molecular and phenotype information. Because few existing visual analytical systems provide appropriate capabilities, we developed a prototypical visual analytical system called iCircos, which enables the simultaneous and interactive exploration of molecular and phenotype information. We discuss our overall method for developing the prototype by integrating user needs and design heuristics from visual analytics, with agile programming in HTML5 and SVG. A demonstration of the prototype to explore molecular and phenotype associations in two disease datasets suggests that iCircos has the potential to accelerate transla...

• Type: Journal
• Year: 2012
• Where: IHI
• Authors: Suresh K. Bhavnani, Mamta Abbas, Vickie McMicken, Numan Oezguen, Jeffry A. Tupa
• Keywords: Design Heuristics, Healthcare, IHI 2012, Information Interfaces, Simultaneous Representation