—In the past decade, artificial neural networks (ANNs) have been widely applied to the engineering problems with a complicated system. ANNs are becoming an important alternative option for solving problems in comparison to traditional engineering solutions, which are usually involved in complicated mathematical theories. In this study, we apply an ANN model to the wave-induced seabed liquefaction problem, which is a key issue in the area of coastal and ocean engineering. Furthermore, we adopted an ANN model with preprocessing (MIN-MAX) on difficult training data. This paper demonstrates the capacity of the proposed ANN model using MIN-MAX pre-processing to provide coastal engineers with another effective tool to analyse the stability of seabed sediment.