Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge s

The organization and mining of malaria genomic and post-genomic data is important to significantly increase the knowledge of the biology of its causative agents, and is motivated, on a longer term, by the necessity to predict and characterize new biological targets and new drugs. Biological targets are sought in a biological space designed from the genomic data from Plasmodium falciparum, but using also the millions of genomic data from other species. Drug candidates are sought in a chemical space containing the millions of small molecules stored in public and private chemolibraries. Data management should, therefore, be as reliable and versatile as possible. In this context, five aspects of the organization and mining of malaria genomic and post-genomic data were examined: 1) the comparison of protein sequences including compositionally atypical malaria sequences, 2) the high throughput reconstruction of molecular phylogenies, 3) the representation of biological processes, particular...

• Type: Journal
• Year: 2006
• Where: CORR
• Authors: L.-M. Birkholtz, Olivier Bastien, G. Wells, D. Grando, F. Joubert, Vinod Kasam, Marc Zimmermann, Philippe Ortet, Nicolas Jacq, Sylvaine Roy, Martin Hofmann-Apitius, Vincent Breton, A. I. Louw, Eric Maréchal
• Keywords: Biological, Biological Targets, CORR 2006, Education, Genomic Data