Asthma is a leading chronic disease of children and currently affects about 6.2 million (8.5%) children in the United States. National Asthma Education and Prevention Program (NAEPP) Guidelines recommend a multimodal chronic care approach. However, both of the 1997 and 2007 NAEPP guidelines have not been widely adopted by primary care clinicians because implementing the guidelines in primary care setting requires changes and redesign in clinical practice and the use of Health Information Technology (HIT) to facilitate the changes. Existing electronic asthma care systems are either inefficient to be used in real clinical encounter or provide only after-fact feedback. This paper introduces a web-based clinical decision support system that integrates intelligent computer technology, complex guideline guidance and knowledge necessary for operationalizing guidelines to improve decision making for asthma care. This system is capable of collecting guideline-suggested diagnostic measures, aut...