: A pilot interface system is developed for computer-aided diagnostic and interventional assistance of cardiologists based on clinical trials. The system includes optimized methods for processing and presentation of cardiological knowledge and data. The multimodal principle of the interface is based on know-how tests of a new magnetic microsensor for detection of catheter navigation in images from angiograms and intra-vascular ultrasound and on new investigations of the principle of operation of the electrocardiograph. The user interface includes interactive access to the clinical database and a cognitive approach to disease visualization. Key words: Cardiovascular diagnosis, angiogram and intravascular ultrasound analysis, catheter path reconstruction, magneto-sensitivity.