— we propose a predictive location based relaying for hybrid cellular and ad-hoc systems that can provide interference minimization to uplink transmission. Location Information Server (LIS) managed the mobile's routing information with centralized scheme. To maintain the routing correctness, mobile must send location information within a relatively short time period. However the tradeoff as the location-update period decreases is the increase in the overall cellular overhead. To overcome this problem, a predictive location-based routing scheme is proposed. Simulation results show that interference is greatly improved with very low cellular overheads.