This paper proposes a simple and efficient decision feedback equalizer (DFE) for Discrete Fourier Transform-Spread Orthogonal Frequency Division Multiplex (DFT-S OFDM) system in Evolved-Universal Telecommunication Radio Access (E-UTRA) [1] uplink transmission. Through cyclic detection and iteration, the new algorithm obtains a noticeable gain than conventional DFE, and is almost as effective as the modified UW based methods but with much higher bandwidth efficiency. Furthermore, it does not need to change the frame structure of existing protocol. Keywords-iterative DFE; cyclic detection; DFT-S OFDM;