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CSB
2005
IEEE

Joint Genomic and Metabolomic Analysis of Toxic Dose-Response Experiments

14 years 4 months ago
Joint Genomic and Metabolomic Analysis of Toxic Dose-Response Experiments
A methodology has been implemented for analyzing microarray and NMR spectral data obtained from the same set of toxic-exposure dose-response experiments. The NMR spectra additionally track the time course of exposure. Analyses consist of screening the data to eliminate variates with insignificant signal, normalization appropriate to the experimental design, Principal Components Analysis, and nonlinear classification using a Support Vector Machine. It is found that exposure at subtoxic levels can be detected.
Gary L. Jahns, Nicholas J. DelRaso, Mark P. Westri
Added 24 Jun 2010
Updated 24 Jun 2010
Type Conference
Year 2005
Where CSB
Authors Gary L. Jahns, Nicholas J. DelRaso, Mark P. Westrick, Victor Chan, Nicholas V. Reo, Timothy R. Zacharewski
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