The development of the IRIS semantic desktop platform has provided illumination of some important issues associated with the collection and manipulation of knowledge assets that are organized by an ontology. We explore those issues related to the personalization of the workspace and of the knowledge assets manipulated by IRIS users. We show that a topic map can provide a necessary mediation between the formal organization provided by an ontology to serve the needs of semantic interoperability between workstations and the individual’s need to personalize the workspace in a just for me fashion. Keywords Topic map, ontology, semantic desktop, semantic interoperability, knowledge assets, personalization