The concept of automating Web services, specifically the brokering activities, is an active research topic. We need a comprehensive and overarching framework that handles the discovery, differentiation, negotiation and selection processing within the context of workflow management, and addresses the issues related to Virtual Organizations. The goal is to add semantics to Web services to endow them with capabilities currently lacking in the literature, but necessary for their successful deployment in future systems. This paper references how such a framework, called the KDSWS Framework, addresses in an integrated endto-end manner, the life-cycle of activities involved in brokering and managing Semantic Web Services. The following issues are addressed: semantic specification of services' capabilities; brokering the services, workflow management, resource management, interoperation and evolution of the Virtual Organization.