Learning Yeast Gene Functions from Heterogeneous Sources of Data Using Hybrid Weighted Bayesian Networks

We developed a machine learning system for determining gene functions from heterogeneous sources of data sets using a Weighted Naive Bayesian Network (WNB). The knowledge of gene functions is crucial for understanding many fundamental biological mechanisms such as regulatory pathways, cell cycles and diseases. Our major goal is to accurately infer functions of putative genes or ORFs (Open Reading Frames) from existing databases using computational methods. However, this task is intrinsically difficult since the underlying biological processes represent complex interactions of multiple entities. Therefore many functional links would be missing when only one or two source of data is used in the prediction. Our hypothesis is that integrating evidence from multiple and complementary sources could significantly improve the prediction accuracy. In this paper, our experimental results not only suggest that the above hypothesis is valid, but also provide guidelines for using the WNB system fo...

• Type: Conference
• Year: 2005
• Where: CSB
• Authors: Xutao Deng, Huimin Geng, Hesham H. Ali
• Keywords: Bioinformatics, CSB 2005, Data Sets, Fundamental Biological Mechanisms, Gene Functions