In this paper we outline the main lines of research for defining a framework based on Linked Open Data (LOD) for supporting knowledge creation in the Cultural Heritage (CH) field with a particular focus on History of Art research. We delineate the main challenges we need to deal with and we explore the state-of-the-art in LOD publishing systems, LOD citation and authority management. Furthermore, we introduce the idea of computer-aided serendipity in History of Art research with the purpose of contributing to the advancement of the field and to the definition of new methodologies for entity linking and retrieval. 1 Motivation One of the most relevant socio-economical and scientific changes in recent years has been the recognition of data as a valuable asset. The Economist magazine recently wrote that “data is the new raw material of business”; and the European Commission stated that data-related “technology and services are expected to grow from EUR 2.4 billion in 2010 to EU...