The review starts with the assessment of needs for health promotion, particularly drawing upon the aging of the workforce in Europe and U.S. Basic intervention models for work site health promotion programs (WHP) are outlined. Recent findings of WHP outcomes underscore the requirement to integrate health promotion into the management system of the organization. Based on the framework of healthy work organization and of Health Management Systems the research project INOPE is described. The objective is the development, implementation, evaluation and transfer of a holistic health management system within the German tax administration.