The mobile medical information system investigated in the study is developed for mobilizing medical information and knowledge and for matching physicians' multiple needs, including mobility, reliability and time efficiency. This paper is set to investigate physicians' perceptions, intentions and actual use regarding the system in a pilot trial conducted in the Finnish health care sector started from April to September 2003. The results from this empirical survey (N=500, returned N=379) indicate that physicians have rather positive perceptions of the system and future intentions to use it in their work practice. Mobile evidence-based medical guidelines-EBMG and mobile textbooks were the most favourite information sources that physicians might use through a mobile device. Mostly, they would search information about certain treatments, drugs and diseases. Mobile EBMG, Pharmaca Fennica and ICD-10 were their most wanted mobile information contents in the system. The physicians we...