Radio-frequency catheter ablation (RFCA) has become an accepted treatment option for atrial fibrillation (Afib). RFCA of Afib involves isolation of the pulmonary veins under X-ray guidance. For easier navigation, two-dimensional X-ray imaging may take advantage of overlay images derived from static pre-operative 3-D data set to add anatomical details which, otherwise, would not be visible under X-ray. Unfortunately, respiratory and cardiac motion may impair the utility of static overlay images for catheter navigation. We developed a system for image-based 2-D motion estimation and compensation as a solution to this problem. It is based on 2-D catheter tracking facilitated by modelbased registration of an ellipse-shaped model to fluorosocpic images. A mono-plane or a bi-plane X-ray C-arm system can be used. In the first step of the method, a 2-D model of the catheter device is computed. Respiratory and cardiac motion at the site of ablation is then estimated by tracking the cathete...