Modeling Cardiac Ion Channel Conductivity: Model Fitting via Simulation

We describe a Markov state model for a cloned potassium channel of the human heart ( 1KvLQTI ). The parameters of the model are determined by a least-squares fit of predicted vs. measured data. The fitting process is achieved by using the "SPSA" optimizer to sequentially choose trial values of the parameters. At each choice of parameter value, a loss function is computed by simulating the action of the channel at that trial parameter value. When the optimizer has converged, the parameter value represents the best fit.

• Type: Conference
• Year: 1998
• Where: WSC
• Authors: John L. Maryak, Richard H. Smith, Raimond L. Winslow
• Keywords: Cloned Potassium Channel, Modeling And Simulation, Parameter, Parameter Value, WSC 1998