Recently, almost uncontrolled technological progress allows so called high-throughput data collection for sophisticated and complex experimental biological systems analysis. Especially, it concerns the whole cellular genome. Therefore it becomes more and more vital to suggest and elaborate gene network models, which can be used for more complete interpretation of large and complex data sets. The presented paper concerns modeling of interactions in yeast genome. With the reference to previously published papers concerning the same subject, our paper presents a significant improvement in calculation procedure leading to very effective reduction of time of calculation. 1998 ACM Subject Classification I.5.1 Models, I.5.4 Applications Keywords and phrases Fuzzy network, gene expression, time optimization Digital Object Identifier 10.4230/OASIcs.MEMICS.2010.32