In this work, we propose a visual, custom-designed, event-driven interconnect simulation framework to evaluate the performance of off-chip multi-processor/memory communications architectures for line cards. The simulator uses the state-of-the-art software design techniques to provide the user with a flexible, robust and comprehensive tool that can evaluate k-ary n-cube based network topologies under non-uniform traffic patterns. The simulator provides full control over essential network parameters and flow control mechanisms such as virtual channels and sub-channeling. We compare three low-dimensional k-ary n-cube based interconnects that can fit into the physical limitations on line cards, where each one of these interconnects has multiple processor-memory configurations. Performance results show that k-ary n-cube architectures perform better than existing interconnects, and they can sustain current line rates and higher. In addition, we provide performance tradeoffs between multiple...